NeoGenesis Skin Restore Serum
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- Regular price
- $29.00
- Sale price
- $29.00
- Regular price
Skin Restore Serum is the NeoGenesis answer to vitamin A. Instead of traditional retinol, it uses hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to retinoid receptors in the skin.
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Description
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Ingredients
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Frequently Asked Questions
Description
What is NeoGenesis Skin Restore Serum?
NeoGenesis Skin Restore Serum is the NeoGenesis vitamin A serum, built around hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to the skin's retinoid receptors. NeoGenesis pairs it with beta-carotene, carrot root and seed extracts, N-acetyl-D-glucosamine, and nourishing sunflower seed oil and squalane, so the formula supports aging and blemish-prone skin without irritation. Apply one pump after cleansing and your S2RM serum, let it absorb, then moisturize as needed. Available at SkinCrew in 15 mL ($66.50) and 30 mL ($122.50), plus a 5 mL trial size ($29).
Sourced direct from NeoGenesis: guaranteed authentic, batch-fresh, fast US shipping.
The problem
Retinol is the most proven ingredient for lines, tone and texture, and it is also the one most people quit. Traditional retinol has to be converted in the skin before it works, and that conversion comes with weeks of flaking, redness and sensitivity. Reactive skin and blemish-prone skin often never get past the adjustment period, so they never see the results.
Next-generation vitamin A, without the retinol adjustment period.
HPR works on the retinoid receptors directly, so Skin Restore Serum supports collagen and the skin's natural renewal to soften the look of fine lines and wrinkles, encourages cell turnover to improve the appearance of uneven tone, dark spots and dullness, and helps keep pores clear-looking, with far less of the irritation that comes with conventional retinol. Carotenoids and plant oils add antioxidant and comfort support, and NeoGenesis pairs it with Recovery to amplify results.
Key Benefits
How to use
Ingredients
Frequently Asked Questions
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NeoGenesis Skin Restore Serum: next-generation vitamin A, minus the irritation
NeoGenesis Skin Restore Serum is the NeoGenesis answer to vitamin A. Instead of traditional retinol, it uses hydroxypinacolone retinoate (HPR), a next-generation retinoid that binds directly to retinoid receptors in the skin. NeoGenesis cites published studies showing HPR can deliver improvements comparable to prescription tretinoin with significantly less irritation. Around it sit beta-carotene, carrot root and seed extracts, N-acetyl-D-glucosamine, tocopherol and nourishing sunflower seed oil and squalane, so renewal comes with comfort rather than flaking.
It is built for skin that wants the visible benefits of vitamin A: softer fine lines and wrinkles, a more even tone, less visible dark spots, smoother texture and more radiance, plus support for blemish-prone skin by helping keep pores clear. NeoGenesis describes it as suiting aging and blemish-prone skin alike, without irritation. Apply one pump after cleansing and your S2RM serum, let it absorb, then moisturize as needed. Dermatologist recommended and made for all skin types. Available at SkinCrew, an Authorized NeoGenesis US Retailer, with fast US shipping.
🛡️ Authorized NeoGenesis US Retailer Guarantee
NeoGenesis sells through licensed skincare professionals and authorized retailers. SkinCrew sources every unit directly from NeoGenesis, so you receive:
Why Skin Restore Serum Stands Out
- Why HPR. HPR binds directly to the skin's retinoid receptors, which is what sets it apart from traditional retinol. NeoGenesis cites published studies showing improvements comparable to prescription tretinoin with significantly less irritation.
- Renewal and collagen. Vitamin A supports collagen and the skin's natural cell turnover, which is how it softens the look of fine lines and wrinkles and improves the appearance of uneven tone, dark spots and rough texture.
- N-acetyl-D-glucosamine. Included alongside HPR and antioxidants to address multiple visible signs of aging, including uneven tone, dullness and loss of radiance, while keeping skin comfortable.
- Barrier support. Sunflower seed oil, squalane, glycerin and propanediol condition and hydrate, supporting the look of a well-functioning moisture barrier, suppleness and elasticity.
| Feature | Skin Restore Serum | Traditional retinol serums | Low-strength OTC retinols |
|---|---|---|---|
| Form of vitamin A | Hydroxypinacolone retinoate (HPR), binds directly to retinoid receptors | Retinol, requires conversion in the skin | Retinol or retinyl palmitate at low strength |
| Irritation | Formulated to work without irritation, per the studies NeoGenesis cites | Dryness, flaking and redness are common while adjusting | Milder, but often less visible benefit |
| Supporting actives | Carotenoids, N-acetyl-D-glucosamine, tocopherol, squalane and sunflower seed oil | Varies, often minimal | Basic emollients |
| Routine fit | After S2RM serum, one pump, then moisturizer as needed | Evenings only, with a slow ramp | Evenings only |
| How to buy | Authorized retailers only, such as SkinCrew | Varies | Mass retail |
The Skin Restore Serum Profile
What Skin Restore Serum Does
Benefit statements describe the appearance and feel of skin and reflect NeoGenesis product information. Individual results vary.
Who Skin Restore Serum Is For
✅ A strong match for
- Fine lines, wrinkles and early visible signs of aging
- Uneven tone, dark spots, rough texture and dullness
- Blemish-prone or congested skin that also wants anti-aging support
- Anyone who wants vitamin A results but has not tolerated traditional retinol
💡 Tolerance and skin type
NeoGenesis formulates Skin Restore Serum to support aging and blemish-prone skin without irritation, using HPR rather than traditional retinol. It is dermatologist recommended and made for all skin types; if your skin is very reactive, start a few evenings a week and build up, and always follow with moisturizer as needed.
How to Use Skin Restore Serum
Skin Restore Serum Ingredient Deep Dive
Hydroxypinacolone Retinoate (HPR)
A next-generation, non-irritating retinoid form of vitamin A that the skin can use directly. It supports collagen, promotes natural skin renewal and improves the appearance of fine lines and wrinkles.
Beta-Carotene, Carrot Root and Seed Extracts
Carotenoids rich in antioxidants and nutrients that help protect against free radicals, brighten the look of skin and support skin renewal.
Sunflower Seed Oil and Squalane
Lightweight oils that suit blemish-prone skin. They nourish and moisturize while supporting the skin barrier and improving the look of texture and elasticity.
Full ingredient list. Water, Glycerin, Propanediol, Helianthus Annuus (Sunflower) Seed Oil, Dimethyl Isosorbide, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Tocopherol, N-Acetyl-D-Glucosamine, Hydroxyethylcellulose, Squalane, Sodium Benzoate, Hydroxypinacolone Retinoate, Tetrasodium EDTA, Daucus Carota Sativa (Carrot) Root Extract, Daucus Carota Sativa (Carrot) Seed Oil, Beta-Carotene, Ascorbyl Palmitate, Lactic Acid.
Watch: Skin Restore Serum Explained
NeoGenesis made this short product video for Skin Restore Serum, so you can see the texture, the application and where it fits in a routine before you buy.
Real Results with Skin Restore Serum
NeoGenesis publishes before and after photos from its professional partners. These cases used Skin Restore Serum as part of a NeoGenesis routine, and each caption lists every product involved.
Blemish-prone skin. Products used: Recovery, Mandelic Acid 8%, Skin Restore Serum, Barrier Renewal Cream.
Photos courtesy of Christine Simmons, Skin Discovery. Individual results vary.
Blemish-prone skin. Products used: Cleanser, Recovery, Skin Serum, Skin Restore Serum.
Photos courtesy of Srita Edgecomb, The Honey Pot. Individual results vary.
Stubborn dark spots. Products used: Skin Serum, Vibrant C Serum, Recovery, Mandelic Acid 8% and more.
Photos courtesy of Tara Farrar, Emerald Studio for Permanent Makeup. Individual results vary.
Dark spots and uneven tone. Products used: Cleanser, Recovery, Mandelic Acid 8% and more.
Photos courtesy of NeoGenesis. Individual results vary.I was genuinely shocked by the noticeable difference in such a short amount of time.Shared by NeoGenesis
Photos courtesy of NeoGenesis professional partners. Unretouched photos supplied by the brand. Individual results vary.
The Science Behind S2RM
S2RM stands for stem cell released molecules. NeoGenesis describes it as the complete secretome of human fibroblast and adipose mesenchymal stem cells: the growth factors, peptides, cytokines, antioxidants and extracellular vesicles, including exosomes, that these cells naturally release. The products contain conditioned media, the molecules the cells secrete, and no live cells.
The brand names Dr. Raja Sivamani, a dermatologist, as Head of its Scientific Medical Advisory Board, and describes its products as dermatologist recommended. NeoGenesis states that S2RM is patented and that the technology is made for all skin types.
NeoGenesis also publishes research on its product pages under titles such as the ones below. We quote these as brand statements rather than as SkinCrew claims.
- Systems Therapeutics Approach
- Rescue of Degenerating Cells Using S2RM
- Safety Profile of S2RM Technology
Watch: Understanding the S2RM secretome
How to Use Skin Restore Serum in a NeoGenesis Routine
After cleansing and applying your S2RM serum, apply one pump to the face. Wear sunscreen daily, as you would with any vitamin A product. NeoGenesis pairs Skin Restore Serum with Recovery to amplify results.
Step 1: Cleanse
Step 2: Treat
Step 3: Moisturize and Protect
Pairs Well With Skin Restore Serum
NeoGenesis builds its routine in layers: cleanse, S2RM serum, targeted step, moisturizer. These are the products the brand pairs with Skin Restore Serum.
Browse the full range in the NeoGenesis collection, or shop by concern in Anti-aging, Dull skin, Combination skin.
Not Sure Where Skin Restore Serum Fits in Your Routine?
A SkinCrew skincare expert can tell you which NeoGenesis S2RM concentration suits your skin, how to layer Skin Restore Serum with the S2RM serums and what you already use, and what to expect in the first weeks. Consultations are complimentary and we are an Authorized NeoGenesis US Retailer.
Contact Our Skincare ExpertsNeoGenesis Skin Restore Serum is a cosmetic product. This product may increase sun sensitivity: use a broad spectrum sunscreen, wear protective clothing and limit sun exposure while using it. If you are pregnant, breastfeeding or planning to become pregnant, consult a physician before using a vitamin A product. Statements on this page describe the appearance of skin and reflect NeoGenesis product information. Individual results vary.
NeoGenesis Skin Restore Serum FAQ
What is NeoGenesis Skin Restore Serum?
It is the NeoGenesis vitamin A serum. Instead of traditional retinol it uses hydroxypinacolone retinoate (HPR), combined with carotenoids, N-acetyl-D-glucosamine and antioxidants, to provide a comprehensive approach to skin renewal: softer fine lines and wrinkles, a more even tone, smoother texture, more radiance and clearer-looking pores, with both immediate and long-term benefits.
How do I use Skin Restore Serum?
After cleansing and applying your S2RM serum (Recovery, Booster or Skin Serum), apply one pump to the face and allow it to absorb fully. Follow with moisturizer as needed and wear sunscreen during the day. It comes in 5 mL, 15 mL and 30 mL.
Who should use Skin Restore Serum?
NeoGenesis recommends it for anyone looking to improve the appearance of fine lines, wrinkles, uneven tone, rough texture, dullness or early visible signs of aging, and for blemish-prone skin that wants help keeping pores clear. It is especially well suited to people who want the benefits of vitamin A in a gentler formula than traditional retinol products.
What is hydroxypinacolone retinoate (HPR)?
HPR is a next-generation vitamin A ingredient that binds directly to retinoid receptors in the skin, so it does not rely on the conversion steps that retinol needs. NeoGenesis cites published studies showing HPR can deliver improvements comparable to prescription tretinoin while producing significantly less irritation.
How is this different from a regular retinol serum?
Regular retinol has to be converted in the skin before it works, and the adjustment period often brings dryness, flaking and redness. Skin Restore Serum uses HPR, which the skin can use directly, and surrounds it with carotenoids, tocopherol, squalane and sunflower seed oil. NeoGenesis positions it as a comfortable vitamin A option for both aging and blemish-prone skin.
Can I use it with Recovery, vitamin C or exfoliating acids?
Recovery is the pairing NeoGenesis recommends: apply the S2RM serum first, then Skin Restore Serum. The brand also lists Mandelic Acid 8% among its pairings. If you combine vitamin A with an exfoliating acid, consider alternating evenings and keep sunscreen in the routine every day, since acids can increase sun sensitivity.
Are there before and after photos for Skin Restore Serum?
Yes. NeoGenesis publishes before and after case photos from its professional partners, and a selection that used Skin Restore Serum is shown on this page with every product in the routine listed in the caption. Individual results vary.
Is there a video on how to use Skin Restore Serum?
Yes. The NeoGenesis product video on this page walks through Skin Restore Serum, what is in it and how to apply it, and the science video explains the stem cell released molecules behind the line.
Is SkinCrew an authorized NeoGenesis retailer in the US?
Yes. SkinCrew is an Authorized NeoGenesis US Retailer and sources every unit directly from NeoGenesis, so Skin Restore Serum arrives fresh, authentic and covered by the brand guarantee, with fast US shipping.