Collection: skinbetter science

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You are shopping the official skinbetter science US catalog. SkinCrew is an Authorized Physician Partner operating under medical direction, so every AlphaRet, Alto, Mystro, Ampra and sunbetter formula is fresh, authentic and sourced direct from skinbetter science, with fast US shipping.

Why "Authorized" matters for skinbetter science +

skinbetter science is sold only through Authorized Physician Partners, never general retail or marketplaces. Grey-market or diverted stock may be expired or tampered with and carries no brand guarantee. SkinCrew purchases direct from skinbetter science, so the brand guarantee applies to every product you receive.

Preferred Authorized skinbetter science® US Retailer · Authorized Physician Partner

skinbetter science: Award-Winning Clinical Skincare, Authorized in the US

Shop the complete skinbetter science range at 2026 US suggested retail price: AlphaRet® retinoid + AHA, Alto antioxidant serums, Mystro adaptogens, Ampra macro hyaluronic acid, Even tone correctors, Trio hydration, InterFuse® peptides and sunbetter® 100% mineral SPF. SkinCrew is an Authorized Physician Partner under medical direction, so every formula is sourced direct from the brand, fresh and authentic, with fast US shipping.

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  • skinbetter science Intensive AlphaRet® Overnight Cream
    skinbetter science Intensive AlphaRet® Overnight Cream skinbetter science Intensive AlphaRet® Overnight Cream

    skinbetter science Intensive AlphaRet® Overnight Cream

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  • skinbetter science EyeMax AlphaRet® Overnight Cream
    skinbetter science EyeMax AlphaRet® Overnight Cream skinbetter science EyeMax AlphaRet® Overnight Cream

    skinbetter science EyeMax AlphaRet® Overnight Cream

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  • skinbetter science AlphaRet® Overnight Cream
    skinbetter science AlphaRet® Overnight Cream skinbetter science AlphaRet® Overnight Cream

    skinbetter science AlphaRet® Overnight Cream

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  • skinbetter science sunbetter® TONE SMART SPF 68 Sunscreen Compact
    skinbetter science sunbetter® TONE SMART SPF 68 Sunscreen Compact sunbetter® TONE SMART SPF 68 Sunscreen Compact by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science sunbetter® TONE SMART SPF 68 Sunscreen Compact

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    $70.00
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  • skinbetter science Even Tone Correcting Serum
    skinbetter science Even Tone Correcting Serum Even Tone Correcting Serum by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Even Tone Correcting Serum

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    From $132.00
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  • skinbetter science Hydration Boosting Cream
    skinbetter science Hydration Boosting Cream Hydration Boosting Cream by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Hydration Boosting Cream

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    From $105.00
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  • skinbetter science Even Intensive Skin Tone Correcting Serum
    skinbetter science Even Intensive Skin Tone Correcting Serum Even Intensive Skin Tone Correcting Serum by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Even Intensive Skin Tone Correcting Serum

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  • skinbetter science InterFuse® Treatment Cream EYE
    skinbetter science InterFuse® Treatment Cream EYE InterFuse® Treatment Cream EYE by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science InterFuse® Treatment Cream EYE

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    From $135.00
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  • skinbetter science Cleansing Gel
    Cleansing Gel by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer A-Team Duo Advanced Kit by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Cleansing Gel

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    From $48.00
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  • skinbetter science sunbetter® TONE SMART SPF 75 Sunscreen Lotion
    skinbetter science sunbetter® TONE SMART SPF 75 Sunscreen Lotion sunbetter® TONE SMART SPF 75 Sunscreen Lotion by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science sunbetter® TONE SMART SPF 75 Sunscreen Lotion

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    From $35.00
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  • skinbetter science Solo Hydrating Defense MEN
    skinbetter science Solo Hydrating Defense MEN Solo Hydrating Defense MEN by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Solo Hydrating Defense MEN

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    $180.00
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    $180.00
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  • skinbetter science Glow and Go Set
    skinbetter science Glow and Go Set Glow and Go Set by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Glow and Go Set

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    $350.00
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  • skinbetter science Trio Luxe Moisture Treatment
    skinbetter science Trio Luxe Moisture Treatment Trio Luxe Moisture Treatment by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Trio Luxe Moisture Treatment

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    From $180.00
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  • skinbetter science Ampra® Volumizing Macro HA Serum
    Ampra Volumizing Macro HA Serum by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer Ampra Volumizing Macro HA Serum by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Ampra® Volumizing Macro HA Serum

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  • skinbetter science AlphaRet® Starter Set
    skinbetter science AlphaRet® Starter Set skinbetter science AlphaRet® Starter Set

    skinbetter science AlphaRet® Starter Set

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    $239.00
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    $239.00
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  • skinbetter science sunbetter® SHEER SPF 56 Sunscreen Compact
    skinbetter science sunbetter® SHEER SPF 56 Sunscreen Compact skinbetter science sunbetter® SHEER SPF 56 Sunscreen Compact

    skinbetter science sunbetter® SHEER SPF 56 Sunscreen Compact

    Regular price
    $70.00
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    $70.00
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  • skinbetter science Alto Advanced Defense and Repair Serum
    skinbetter science Alto Advanced Defense and Repair Serum skinbetter science Alto Advanced Defense and Repair Serum

    skinbetter science Alto Advanced Defense and Repair Serum

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    From $195.00
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  • skinbetter science Instant Effect Gel EYE
    skinbetter science Instant Effect Gel EYE Instant Effect Gel EYE by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Instant Effect Gel EYE

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    $115.00
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  • skinbetter science BioRewind™ Skin Health Dietary Supplement
    skinbetter science BioRewind™ Skin Health Dietary Supplement BioRewind™ Skin Health Dietary Supplement by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science BioRewind™ Skin Health Dietary Supplement

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    $135.00
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    $135.00
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  • skinbetter science InterFuse® Intensive Treatment LINES
    skinbetter science InterFuse® Intensive Treatment LINES InterFuse® Intensive Treatment LINES by skinbetter science, texture | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science InterFuse® Intensive Treatment LINES

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    From $145.00
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  • skinbetter science sunbetter® SHEER SPF 70 Sunscreen Lotion
    skinbetter science sunbetter® SHEER SPF 70 Sunscreen Lotion sunbetter® SHEER SPF 70 Sunscreen Lotion by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science sunbetter® SHEER SPF 70 Sunscreen Lotion

    Regular price
    $75.00
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    $75.00
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  • skinbetter science Detoxifying Scrub Mask
    Detoxifying Scrub Mask by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer Detoxifying Scrub Mask by skinbetter science, packaging | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Detoxifying Scrub Mask

    Regular price
    $65.00
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  • skinbetter science Mystro® Active Balance Serum
    skinbetter science Mystro® Active Balance Serum Mystro® Active Balance Serum by skinbetter science | SkinCrew, Preferred Authorized skinbetter science US Retailer

    skinbetter science Mystro® Active Balance Serum

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    From $225.00
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skinbetter science: Award-Winning Clinical Skincare, Authorized in the US

skinbetter science is a physician-dispensed skincare brand built on proprietary, patented technologies: AlphaRet® (the award-winning retinoid + AHA), WEL/TAP antioxidants with Allyl PQQ, P.A.T.H. plant adaptogens, HYAsync macro hyaluronic acid, Trio hydration, InterFuse® delivery, the NOw Complex, CORExtract and sunbetter® 100% mineral SPF. Every formula is dermatologist tested, non-comedogenic, formulated without parabens, fragrance and dyes, and documented in physician-led clinical studies and peer-reviewed journals.

skinbetter science sells only through Authorized Physician Partners, never general retail or open marketplaces. SkinCrew is an Authorized Physician Partner under medical direction, so every AlphaRet, Alto, Mystro, Ampra, Even, Trio, InterFuse and sunbetter product is sourced direct from the brand, fresh and authentic, at US suggested retail price (SRP) with fast shipping. Below: the science, the bestsellers, the full range, a concern guide, clinical results and the answers shoppers ask for most.

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Proprietary Technology Platforms

Patented, brand-exclusive technologies: AlphaRet, WEL/TAP, P.A.T.H., b.r.y.t., HYAsync, Trio, InterFuse, NOw Complex, CORExtract and sunbetter A.M.P., not off-the-shelf actives.

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57 Clinical Studies

Efficacy and tolerability evaluated in clinical studies led by board-certified dermatologists and physicians, many published in peer-reviewed dermatology journals.

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Dermatologist Tested & Clean

Dermatologist tested, non-comedogenic, cruelty free, and formulated without parabens, fragrance and dyes.

🛡️

Authorized & Authentic

SkinCrew is an Authorized Physician Partner under medical direction. Direct supply from skinbetter science: never grey-market, expired or diverted stock.

The Science Behind skinbetter science

skinbetter science develops its own technologies to solve specific formulation problems: retinoid irritation, incomplete antioxidant protection, hyaluronic acid that degrades too fast, delivery of large molecules, elegance of mineral SPF. Here is what each platform does and which products use it.

Rejuvenate

AlphaRet® Technology

A patented double-conjugated molecule: a retinoid and lactic acid (an AHA) bonded together to address the tolerability versus efficacy tradeoff of retinoid therapy. Visible rejuvenation with little-to-no irritation, nightly. In AlphaRet Overnight Cream, Intensive AlphaRet, Clearing Serum, EyeMax, Body Overnight Cream and Peel Pads.

Protect

WEL/TAP Antioxidant Technology

Protection beyond vitamins C and E to 17 further antioxidants, defending against extrinsic and intrinsic oxidative stress. TAP adds patented Allyl PQQ, the antioxidant at the heart of Alto Advanced Defense and Repair Serum. Solo MEN and Even Intensive share the platform.

Balance

P.A.T.H. Technology

A proprietary system of plant adaptogens supporting skin’s ability to adapt to stress. Mystro Active Balance targets the visible effects of unbalanced skin: redness, texture, dullness, pores, pigmentation. Mystro Revive pairs 13 adaptogens with TAP for skin affected by hormonal decline.

Brighten

b.r.y.t. & b.r.y.t.e.r. Technology

b.r.y.t. visibly reduces discoloration and improves the look of redness, yellowness and sallowness, without hydroquinone or retinol. b.r.y.t.e.r. adds resurfacing for stubborn discoloration. In Even Tone and Even Intensive Skin Tone Correcting Serums.

Hydrate

Trio Technology

Targets the three elements of natural moisturization: hyaluronic acid, lipids (ceramides, cholesterol, fatty acids) and natural moisturizing factors, supporting barrier function. Trio Rebalancing is lightweight, Trio Luxe is the rich version for dry skin.

Deliver

InterFuse® Technology

A patented delivery system that amplifies delivery of intact macro-molecules such as injectable-grade hyaluronic acid and peptides, no needles required. Powers InterFuse Intensive Treatment LINES, Treatment Cream FACE & NECK and Treatment Cream EYE.

Volumize

HYAsync Technology

Alpha-lipoic acid structurally bonded to hyaluronic acid, forming novel HA molecules built to deliver and sustain HA by shielding it from rapid degradation. The technology behind Ampra Volumizing Macro HA Serum, formulated to visibly plump, lift and redefine contours where skin reads deflated rather than lined.

Neck

NOw Complex

Harnesses the body’s natural nitric oxide (NO) process to address the aging needs of delicate neck skin. The patented NOw Complex (arginine, adenosine, carnosine plus a stabilizer) is the core of Techno Neck Perfecting Cream.

From Within

CORExtract Biotechnology

Rosemary-derived rosmarinic acid with synergistic antioxidants, shown in clinical testing to reverse glycation and reduce Advanced Glycation Endproducts (AGEs) that damage collagen and elastin. BioRewind is the daily oral supplement built on it.

Shield

sunbetter® A.M.P.

Resolves the tradeoff between mineral effectiveness, elegance and compliance: 100% mineral (zinc oxide, titanium dioxide) broad spectrum sunscreens up to SPF 75, also screening infrared, blue light and pollution, in lotion, compact and stick formats tested after in-office treatments.

Descriptions reflect skinbetter science published product information. These are cosmetics, and individual results vary.

Shop the Full skinbetter science Range

All 35 skinbetter science products at SkinCrew by pillar: Rejuvenate, Enhance, Protect, Refresh, plus regimens and sets. Prices are 2026 US SRP for the lowest-priced full size, with travel packs excluded.

Which skinbetter science Products Are Right for You?

New to skinbetter science? Start with your primary concern: these are the products our clinical team reaches for first.

How skinbetter science Compares

Where skinbetter science sits against prescription retinoids, typical medical-grade brands and drugstore skincare. Each has its place: the right fit depends on your skin and goals.

SKINBETTER SCIENCE vs OTHER SKINCARE TIERS
Featureskinbetter sciencePrescription RetinoidsTypical Medical-GradeDrugstore / OTC
Where it’s soldAuthorized Physician Partners onlyPharmacy, with a prescriptionClinics & authorized retailersGeneral retail
Retinoid approachAlphaRet: retinoid + AHA in one patented molecule, nightlyRetinoic acid; effective, often irritatingRetinol or encapsulated retinolLow-strength retinol
Antioxidant defenseVitamins C & E + 17 more, plus patented Allyl PQQNot applicableUsually vitamin C / E / ferulicSingle antioxidants
Clinical evidencePhysician-led studies, peer-reviewed publicationsExtensive drug trialsVaries by brandLimited
Sun protection100% mineral, up to SPF 75, tone-adapting formatsNot applicableMineral or chemical, SPF 30 to 50Mostly chemical filters

Typical characteristics of each tier, not specific competitor products. skinbetter science products are cosmetics, not drugs, and not a substitute for a prescription.

Clinical Results at a Glance

Results reported by skinbetter science from physician-led clinical studies.

33%1
improvement in the appearance of fine lines, wrinkles & tone at 12 weeks
AlphaRet Overnight Cream
42%2
improvement in the appearance of skin dullness after 12 weeks
Alto Advanced Defense and Repair Serum
29%3
improvement in the appearance of skin tone after 12 weeks
Solo Hydrating Defense MEN
42%4
mean improvement in the appearance of pigmentation at 12 weeks
Even Intensive Skin Tone Correcting Serum
116%5
mean increase in hydration after 8 weeks
Trio Luxe Moisture Treatment
32%6
improvement in the appearance of elasticity after 16 weeks
Mystro Revive Renewing Serum
28%7
reduction in skin redness after 12 weeks
BioRewind Skin Health Dietary Supplement
22%8
improvement in the appearance of lines, wrinkles & tone at 8 weeks
Techno Neck Perfecting Cream
>20%9
improvement in fine lines, wrinkles & crow's feet at 8 weeks
InterFuse Intensive Treatment LINES
32%10
improvement in the appearance of plumpness after 12 weeks
Ampra Volumizing Macro HA Serum

1 Dermatologist-led clinical trial, 48 subjects, nightly use, 12 weeks from baseline. 2 Physician-led clinical trial, 39 patients, twice-daily use, 12 weeks from baseline. 3 Dermatologist-led clinical trial, 25 patients, once-daily use, 12 weeks from baseline. 4 Average Melasma Area and Severity Index (MASI) measurements from baseline at 12 weeks, Even Intensive used alone (n=40). 5 Corneometer mean percent improvement, 8-week dermatologist-led trial, 27 subjects with dry, dehydrated skin, twice-daily use.

6 Improvement in the appearance of elasticity at 16 weeks as reported by skinbetter science (N=53). 7 12-week double-blinded, randomized trial, 52 subjects. 8 Trial by two board-certified dermatologists, 36 subjects of varying skin tones, twice-daily use, 12 weeks. 9 Dermatologist-led clinical trial, 25 patients, twice-daily use, 8 weeks from baseline. 10 Dermatologist-led clinical trial in 65 women with visible volume loss, twice-daily use, 12 weeks from baseline (N=65).

Sunburn Alert: AlphaRet products contain an alpha hydroxy acid (AHA) that may increase your skin’s sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards. Caution: AlphaRet products contain retinoid in a topical form. If you are pregnant, lactating or planning to become pregnant, consult a physician before use. If using more than one exfoliating product, irritation may occur.

skinbetter science: Frequently Asked Questions

What is skinbetter science?

skinbetter science is a US physician-dispensed clinical skincare brand built on patented technologies: AlphaRet (retinoid plus AHA), WEL/TAP antioxidants with Allyl PQQ, P.A.T.H. plant adaptogens, HYAsync macro hyaluronic acid, Trio hydration, InterFuse delivery and sunbetter mineral SPF. Formulas are dermatologist tested, non-comedogenic and clinically studied.

Is skinbetter science medical grade?

Yes. skinbetter science is physician-dispensed and sold only through Authorized Physician Partners such as SkinCrew, which operates under medical direction. Its technologies are evaluated in clinical studies led by board-certified dermatologists, many of them published. It is a cosmetic line, so it complements prescription therapy rather than replacing it.

Where can I buy skinbetter science in the US?

Buy skinbetter science from an Authorized Physician Partner. SkinCrew is an authorized US partner operating under medical direction and buys every unit directly from the brand, so you get fresh, authentic product, full brand guarantee coverage, current US suggested retail pricing and fast nationwide shipping.

Why can't I buy skinbetter science on Amazon?

Because skinbetter science restricts distribution to Authorized Physician Partners. Marketplace listings on Amazon or eBay are not authorized: that stock is typically diverted or grey-market, may be expired, heat-damaged or tampered with, and carries no brand guarantee. An authorized partner like SkinCrew is the only way to confirm authenticity.

What is the difference between AlphaRet and tretinoin?

Tretinoin is prescription retinoic acid: highly effective and frequently irritating. AlphaRet is a patented cosmetic molecule that double-conjugates a retinoid with lactic acid, an AHA, to address the tolerability versus efficacy tradeoff. skinbetter science reports a 33% average improvement in fine lines, wrinkles and tone at 12 weeks with little-to-no irritation.

How do I start a skinbetter science routine?

Start with the A-Team: Alto Advanced Defense and Repair Serum each morning, AlphaRet Overnight Cream each night, and a sunbetter mineral sunscreen daily. Add Cleansing Gel and a Trio moisturizer. The A-Team Duo Advanced Kit and AlphaRet Starter Set are easy entry points.

What is Ampra Volumizing Macro HA Serum?

Ampra Volumizing Macro HA Serum is the skinbetter science twice-daily volume serum, powered by HYAsync technology, which bonds alpha-lipoic acid to hyaluronic acid so the HA resists rapid degradation. A 12-week dermatologist-led trial of 65 women recorded 32% improvement in plumpness, 23% in lift and 40% in texture.

How is Ampra different from a regular hyaluronic acid serum?

Conventional hyaluronic acid serums deliver free HA that degrades quickly and mostly hydrates the surface. Ampra uses HYAsync to bond alpha-lipoic acid to hyaluronic acid, helping sustain it. It targets the appearance of volume, lift and lower face contour rather than hydration alone, and layers under a retinoid.

Can I use skinbetter science with other brands?

Yes. skinbetter science layers into most routines, and many SkinCrew clients pair it with AlumierMD or Colorescience. The main caution is stacking exfoliants: AlphaRet formulas contain an AHA, so combining several exfoliating products may irritate. Introduce one new active at a time and finish mornings with SPF.

Is skinbetter science safe during pregnancy?

Ask your physician first. AlphaRet products contain a topical retinoid, and skinbetter science advises anyone pregnant, lactating or planning pregnancy to consult a physician before use. Many clients continue Cleansing Gel, Trio moisturizers, Ampra and sunbetter mineral SPF under medical guidance, as none contain a retinoid.

What does sunbetter sunscreen do?

sunbetter sunscreens are 100% mineral, zinc oxide and titanium dioxide, broad spectrum formulas up to SPF 75. They help prevent sunburn and, used as directed with other sun protection measures, decrease the risk of skin cancer and early skin aging caused by the sun. Water resistant 80 minutes.

How much does skinbetter science cost?

Prices run from $50 for Refining Foam Cleanser to $350 for the Glow and Go Set, with most treatment serums between $145 and $275 for a full size. Every Authorized Physician Partner sells at US suggested retail price, so a listing far below SRP signals an unauthorized seller.

✅ Reviewed by the SkinCrew Clinical Team

This guide is maintained by the SkinCrew Clinical Team under medical direction. As an Authorized Physician Partner of skinbetter science we source directly from the brand and handle these formulas daily, from storage and freshness to matching products to real concerns. It reflects skinbetter science published guidance and clinical data, and is educational, not personalized medical advice.

Explore Concerns & Ingredients skinbetter science Targets

The concern, ingredient, category and brand hubs skinbetter science products most often appear in at SkinCrew.

Not sure which skinbetter science products are right for you?

Our clinical skincare specialists can build a complete skinbetter science regimen matched to your skin and goals, from cleanser to Ampra to AlphaRet to sunbetter SPF.

Talk to a SkinCrew Specialist
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