NeoGenesis MB-2
- Regular price
- $30.00
- Sale price
- $30.00
- Regular price
MB-2 is the NeoGenesis probiotic occlusive balm for skin that has run out of options: very dry, compromised, visibly disrupted skin that feels tight, itchy or raw.
PREFERRED AUTHORIZED RETAILER
ENJOY FREE SHIPPING $99+
PROTECTED & SECURE DELIVERY
-
Description
-
Key Benefits
-
How to use
-
Ingredients
-
Frequently Asked Questions
Description
What is NeoGenesis MB-2?
NeoGenesis MB-2 is the NeoGenesis rescue step: a probiotic occlusive balm that instantly soothes very dry and compromised skin with immediate barrier and microbiome support from 5 live probiotic bacteria. Castor and hydrogenated castor seed oil form a protective layer that locks in moisture and shields against external irritants, and sunflower seed oil replenishes the lipid barrier. Warm a small amount between your fingertips, dab it onto the area, and use it as the final step over any serums or creams. Available at SkinCrew in 55 g ($98), plus a 6 g trial size ($30).
Sourced direct from NeoGenesis: guaranteed authentic, batch-fresh, fast US shipping.
The problem
Very dry, flaking, tight or visibly disrupted skin, including skin during and after professional treatments, needs to be protected while it recovers, and the usual occlusives are petrolatum-based balms that seal everything out, including the beneficial bacteria the barrier depends on. Rich creams alone are not occlusive enough to stop the water loss.
Occlusive protection with live probiotics, for skin that needs rescuing.
MB-2 does both jobs at once. The castor-based balm forms a breathable protective layer that holds moisture in and keeps irritants out, sunflower oil feeds the lipid barrier, and the five live strains help balance the skin's microbiome while the skin's own barrier renews itself. NeoGenesis positions it for moderate to severe dryness and for moisture-depleted, stressed or compromised skin; it helps calm the look of redness, flaking, tightness and itching and supports lasting comfort.
Key Benefits
How to use
Ingredients
Frequently Asked Questions
45 Day Satisfaction Guarantee with Checkout+
Try your new skincare and devices with confidence.
If you are not satisfied, return them within 45 days for a full refund or exchange.
- Free return labels
- 45 days start on delivery
- 5% bonus cashback
- Protection against damage & theft
To qualify, you must select Checkout+ at purchase.
If not selected, the standard return policy applies.
Recommended Products
You might also like these
Free Shipping
Free US wide shipping for orders $99+.
Authorized Retailer
Our products are 100% genuine, we only sell products we truly believe in.
Earn Cashback
Join The Crew and earn up to 20%* cashback on every purchase. Redeem your rewards for products and save.
Shop with Confidence
Every order is backed by secure shipping and our 45-Day Satisfaction Guarantee.*
NeoGenesis MB-2: instant barrier and microbiome support in one balm
NeoGenesis MB-2 is the NeoGenesis probiotic occlusive balm for skin that has run out of options: very dry, compromised, visibly disrupted skin that feels tight, itchy or raw. It provides immediate barrier and microbiome support from 5 live probiotic bacteria, Bacillus coagulans, Bacillus subtilis, Lactobacillus plantarum, Lactococcus lactis and Lactobacillus crispatus, suspended in castor and sunflower seed oils. The occlusive layer locks in moisture while the skin's own barrier renews itself underneath.
NeoGenesis positions MB-2 for moderate to severe dryness and for skin that is moisture-depleted, stressed or compromised during and after professional treatments. It helps calm the look of redness, flaking, tightness and itching, supports the skin's natural recovery and improves overall comfort, and the live strains help restore balance to the skin's microbiome so sensitivity and recurring visible irritation are less of a pattern. It is always the final step. Available at SkinCrew, an Authorized NeoGenesis US Retailer, with fast US shipping.
🛡️ Authorized NeoGenesis US Retailer Guarantee
NeoGenesis sells through licensed skincare professionals and authorized retailers. SkinCrew sources every unit directly from NeoGenesis, so you receive:
Why MB-2 Stands Out
- Why a probiotic balm. Compromised skin often has an imbalanced microbiome as well as a leaky barrier. Live bacteria encourage flora diversity and natural microbial competition, which NeoGenesis links to calmer, more resilient skin that is less prone to visible irritation and imbalance.
- Occlusion done with castor oil. Hydrogenated castor seed oil forms a protective occlusive layer that instantly locks in moisture, limits water loss and shields against external irritants while the skin's natural recovery process continues underneath.
- Sunflower seed oil lipids. Rich in essential fatty acids that help replenish and strengthen the skin's natural lipid barrier, improving softness, comfort and overall resilience.
- Antioxidant support. Ascorbyl palmitate and tocopheryl acetate, oil-soluble forms of vitamins C and E, round out a short, water-free ingredient list.
| Feature | MB-2 | Single probiotic balms | Plain occlusive balms |
|---|---|---|---|
| Microbiome support | 5 live probiotic strains from four genera | One probiotic or a prebiotic extract | None |
| Occlusive base | Castor and hydrogenated castor seed oil with sunflower seed oil | Varies | Petrolatum or mineral oil |
| Who it is made for | Very dry, compromised, post-treatment and reactive skin | General dry skin | General dry skin |
| Where it sits in a routine | Final step over serums and creams, as often as needed | Typically a moisturizer step | Spot use |
| How to buy | Authorized retailers only, such as SkinCrew | Varies | Mass retail |
The MB-2 Profile
What MB-2 Does
Benefit statements describe the appearance and feel of skin and reflect NeoGenesis product information. Individual results vary.
Who MB-2 Is For
✅ A strong match for
- Very dry, compromised or visibly disrupted skin that needs immediate relief
- Sensitive, reactive skin with recurring visible irritation
- Skin that is moisture-depleted or stressed during and after professional treatments
- Anyone who wants an occlusive final step that also supports the microbiome
💡 Tolerance and skin type
Made for sensitive and compromised skin, with a short, water-free formula of plant oils, live probiotic strains and vitamins C and E. Apply it over Barrier Renewal Cream or Recovery as the last layer rather than underneath other products.
How to Use MB-2
MB-2 Ingredient Deep Dive
Live Probiotic Bacteria
Five live bacterial strains, Bacillus coagulans, Bacillus subtilis, Lactobacillus plantarum, Lactococcus lactis and Lactobacillus crispatus, support a balanced skin microbiome by encouraging flora diversity and natural microbial competition, for calmer, more resilient skin that is less prone to visible irritation and imbalance.
Hydrogenated Castor Seed Oil
Forms a protective occlusive layer on the skin to instantly lock in moisture, limit water loss and shield against external irritants while supporting the skin's natural recovery process.
Sunflower Seed Oil
Rich in essential fatty acids that help replenish and strengthen the skin's natural lipid barrier, improving softness, comfort and overall skin resilience.
Full ingredient list. Castor (Ricinus Communis) Seed Oil, Hydrogenated Castor Oil, Sunflower (Helianthus Annuus) Seed Oil, Bacillus Coagulans, Bacillus Subtilis, Lactobacillus Plantarum, Lactococcus Lactis, Ascorbyl Palmitate, Tocopheryl Acetate, Lactobacillus Crispatus
Watch: MB-2 Explained
NeoGenesis made this short product video for MB-2, so you can see the texture, the application and where it fits in a routine before you buy.
Real Results with MB-2
NeoGenesis publishes before and after photos from its professional partners. These cases used MB-2 as part of a NeoGenesis routine, and each caption lists every product involved.

Post-procedure skin. Products used: Cleanser, Recovery, Barrier Renewal Cream, MB-2.
Photos courtesy of Dr. Martha Viera. Individual results vary.
Post-procedure skin. Products used: Cleanser, Recovery, Barrier Renewal Cream and more.
Photos courtesy of Nancy Trazcinski, FNP, DCNP. Individual results vary.Photos courtesy of NeoGenesis professional partners. Unretouched photos supplied by the brand. Individual results vary.
The Science Behind S2RM
S2RM stands for stem cell released molecules. NeoGenesis describes it as the complete secretome of human fibroblast and adipose mesenchymal stem cells: the growth factors, peptides, cytokines, antioxidants and extracellular vesicles, including exosomes, that these cells naturally release. The products contain conditioned media, the molecules the cells secrete, and no live cells.
The brand names Dr. Raja Sivamani, a dermatologist, as Head of its Scientific Medical Advisory Board, and describes its products as dermatologist recommended. NeoGenesis states that S2RM is patented and that the technology is made for all skin types.
NeoGenesis also publishes research on its product pages under titles such as the ones below. We quote these as brand statements rather than as SkinCrew claims.
- Systems Therapeutics Approach
- Rescue of Degenerating Cells Using S2RM
- Safety Profile of S2RM Technology
Watch: Why stem cell released molecules are used in skincare
How to Use MB-2 in a NeoGenesis Routine
Dispense MB-2 onto your fingertips and rub them together to warm the balm. Use as the final step if layering multiple products. Reapply as often as needed. Available in 6 g and 55 g.
Step 1: Cleanse
Step 2: Treat
Step 3: Moisturize and Protect
Pairs Well With MB-2
NeoGenesis builds its routine in layers: cleanse, S2RM serum, targeted step, moisturizer. These are the products the brand pairs with MB-2.
Browse the full range in the NeoGenesis collection, or shop by concern in Sensitive skin, Dry skin, What's new.
Shop Related Skincare
The brand, category and concern pages this product belongs to at SkinCrew.
Read the Guides
Side-by-side comparisons and brand guides from The Skin Edit.
Not Sure Where MB-2 Fits in Your Routine?
A SkinCrew skincare expert can tell you which NeoGenesis S2RM concentration suits your skin, how to layer MB-2 with the S2RM serums and what you already use, and what to expect in the first weeks. Consultations are complimentary and we are an Authorized NeoGenesis US Retailer.
Contact Our Skincare ExpertsNeoGenesis MB-2 is a cosmetic product. It contains live probiotic bacteria and no stem cells. Statements on this page describe the appearance of skin and reflect NeoGenesis product information. Individual results vary.
NeoGenesis MB-2 FAQ
What is a probiotic balm?
A probiotic balm is a skincare product formulated to support the skin's natural microbiome and its protective barrier. NeoGenesis MB-2 combines five live probiotic strains with nourishing castor and sunflower seed oils to reinforce the skin's barrier and lock in moisture.
What does probiotic skincare do for the skin?
MB-2 helps balance the skin's natural microbiome while nourishing dry, sensitive skin. Its blend of live probiotic strains and botanical oils supports the skin barrier and helps reduce the appearance of irritation, sensitivity, itching and flare-ups of redness.
Does a probiotic balm help the skin barrier?
Yes. MB-2 nourishes dry skin while supporting the skin's natural protective barrier. The live probiotic strains, castor oil and sunflower seed oil work together to give lasting moisture while helping skin feel softer, more comfortable and more balanced.
How is MB-2 different from other probiotic skincare?
Many probiotic skincare products rely on a single probiotic ingredient. MB-2 features five live probiotic strains, Bacillus coagulans, Bacillus subtilis, Lactobacillus plantarum, Lactococcus lactis and Lactobacillus crispatus, in an occlusive balm of botanical oils, so it supports the microbiome while delivering long-lasting hydration.
Can I use MB-2 every day?
Yes. MB-2 is formulated for daily use and can be applied as often as needed to keep skin soft, hydrated and comfortable. Regular use helps replenish moisture, support the skin's natural microbiome and reinforce the skin barrier.
When in my routine should I apply MB-2?
Always last. Warm a small amount between your fingertips, dab it gently over the area, and apply it after any serum or cream, such as Recovery or Barrier Renewal Cream. As an occlusive it seals in everything underneath, which is why NeoGenesis calls it the final step.
Are there before and after photos for MB-2?
Yes. NeoGenesis publishes before and after case photos from its professional partners, and a selection that used MB-2 is shown on this page with every product in the routine listed in the caption. Individual results vary.
Is there a video on how to use MB-2?
Yes. The NeoGenesis product video on this page walks through MB-2, what is in it and how to apply it, and the science video explains the stem cell released molecules behind the line.
Is SkinCrew an authorized NeoGenesis retailer in the US?
Yes. SkinCrew is an Authorized NeoGenesis US Retailer and sources every unit directly from NeoGenesis, so MB-2 arrives fresh, authentic and covered by the brand guarantee, with fast US shipping.

