skinbetter science InterFuse® Intensive Treatment LINES
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- $245.00
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- $245.00
- Regular price
skinbetter science InterFuse Intensive Treatment LINES is a no-needle, twice-daily hyaluronic acid treatment that visibly improves deep expression lines around the eyes, forehead, upper lip and smile lines, for anyone avoiding injections or maintaining between appointments.
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Description
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Frequently Asked Questions
Description
What is skinbetter science InterFuse® Intensive Treatment LINES?
InterFuse Intensive Treatment LINES is a targeted, twice-daily topical built on patented InterFuse Technology, a delivery system that carries intact macromolecules into the skin without needles. It pairs injectable-grade hyaluronic acid with four additional hyaluronic acids of varying molecular weights, peptides that help expression lines appear smoother on application, and a collagen complex of amino acids, peptides and Vitamin C. You apply it as the first step of your routine, only where lines form: crow's feet, forehead lines, upper-lip lines and smile lines. It is paraben, fragrance, dye, gluten and phthalate free. Available at SkinCrew in 15 ml ($145) and 30 ml ($245), plus a 6 x 5 ml travel pack ($312).
Sourced direct through official skinbetter science channels: guaranteed authentic, batch-fresh, fast US shipping.
The problem
Expression lines are the hardest wrinkles to argue with. Crow's feet, forehead lines, smile lines and the vertical lines above the lip are carved in by thousands of repeated movements, and once they are visible at rest, a standard moisturizer or a thin hyaluronic acid serum does very little. The ingredients that could help, large intact macromolecules such as injectable-grade hyaluronic acid, are simply too big to get where they need to be.
A no-needle hyaluronic acid solution for deep expression lines.
That is the problem InterFuse Technology was built to solve. This patented delivery system amplifies the delivery of intact macromolecules, carrying injectable-grade hyaluronic acid, peptides and a collagen complex into targeted areas without a needle. In a dermatologist-led clinical trial of 25 patients using the product twice daily, improvements were visible from four weeks, with over 20% improvement in the appearance of fine lines, wrinkles, forehead lines and crow's feet at eight weeks. Used alongside InterFuse Treatment Cream FACE and NECK, average improvement reached 79% for facial texture at 12 weeks.
Key Benefits
How to use
Ingredients
Frequently Asked Questions
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skinbetter science InterFuse® Intensive Treatment LINES: Injectable-Grade Hyaluronic Acid, No Needle Required.
skinbetter science InterFuse Intensive Treatment LINES is the no-needle answer to deep expression lines. Patented InterFuse Technology amplifies the delivery of intact macromolecules, carrying injectable-grade hyaluronic acid, four additional hyaluronic acids, peptides and a collagen complex of amino acids and Vitamin C into the areas that move most: crow's feet, forehead lines, upper-lip lines and smile lines. In a dermatologist-led clinical trial, twice-daily use produced over 20% improvement in the appearance of fine lines, wrinkles and crow's feet at eight weeks, with visible change from week four. Paraben, fragrance, dye, gluten and phthalate free. Available in 15 ml and 30 ml from SkinCrew, a Preferred Authorized skinbetter science US Retailer.
🛡️Authorized skinbetter science US Retailer Guarantee
skinbetter science is sold only through Authorized Physician Partners. SkinCrew is an Authorized Physician Partner operating under medical direction, sourcing every unit directly from skinbetter science (L'Oréal Dermatological Beauty), so you receive:
Why InterFuse Intensive Treatment LINES Stands Out
- A delivery system, not just an ingredient list. Large intact macromolecules struggle to get past the skin surface. InterFuse Technology is patented specifically to amplify their delivery, which is what makes topical injectable-grade hyaluronic acid a sensible proposition rather than a marketing line.
- Published clinical evidence. Efficacy and tolerability of the hyaluronic acid serum and the peptide-rich cream in subjects with photodamaged skin were published in the Journal of Cosmetic Dermatology, 2022, following first presentation at the Maui Dermatology Conference in 2017.
- Immediate smoothing plus long-term change. Peptides help expression lines appear smoother on application, while the hyaluronic acid system drives the measured improvement recorded at four and eight weeks.
- Better together. Layered with InterFuse Treatment Cream FACE & NECK, average improvement from baseline reached 79% in facial skin texture and 50% in lines and wrinkles at 12 weeks.
| Feature | InterFuse Intensive Treatment LINES | In-Office Dermal Filler | Standard Hyaluronic Acid Serum |
|---|---|---|---|
| Format | Topical, applied at home twice daily | Injection performed by a clinician | Topical, applied at home |
| Hyaluronic acid used | Injectable-grade HA plus four additional molecular weights | Cross-linked injectable HA gel | Usually one or two molecular weights |
| Delivery | Patented InterFuse Technology for intact macromolecules | Needle or cannula | Relies on the formula base alone |
| Downtime | None | Possible swelling or bruising | None |
| Published data on the finished product | Yes, J Cosmet Dermatol, 2022 | Yes, product specific | Rarely published |
The InterFuse Intensive Treatment LINES Profile
Clinically Shown Results
Average improvement evaluated in a board-certified dermatologist-led clinical trial in 25 patients with twice-daily use over 8 weeks from baseline. Combination data: when used with InterFuse Treatment Cream FACE & NECK, average improvements from baseline were 50% in facial skin texture at week 8, and 79% and 50% in facial skin texture and lines and wrinkles respectively at week 12 (J Cosmet Dermatol, 2022). Unretouched clinical photography on clean, product-free skin. Individual results vary.
Who It Is For (and Who Should Skip It)
LINES is a strong fit if
- Crow's feet, forehead lines, smile lines or upper-lip lines are visible when your face is at rest.
- You would rather not have injections, or you want a topical to use between appointments.
- You want a targeted treatment you can apply precisely rather than another full-face cream.
- You already use InterFuse Treatment Cream FACE & NECK and want the amplified pairing.
- Your skin is sensitive or retinoid-intolerant and you need a non-exfoliating anti-wrinkle option.
- You want published clinical evidence behind the product you buy.
Consider something else if
- Your priority is overall photoaging and texture rather than specific lines: start with AlphaRet Overnight Cream.
- You mainly want firmness across the whole face and neck: InterFuse Treatment Cream FACE & NECK covers more ground.
- Under-eye puffiness and darkness are the real issue: InterFuse Treatment Cream EYE is purpose-built for that zone.
- You are after facial volume, lift and contour: Ampra Volumizing Macro HA Serum targets those.
- Discoloration is your dominant concern rather than lines.
- You have a known sensitivity to any ingredient on the list. Review it with your clinician first.
What to Expect: Week by Week
Timings below reflect the dermatologist-led clinical trial in 25 patients using InterFuse Intensive Treatment LINES twice daily over eight weeks, plus the published 12-week combination data. Individual results vary.
Ingredient Deep Dive
Every ingredient below is drawn from the official skinbetter science formulation notes for InterFuse Intensive Treatment LINES. Cosmetic benefits only.
InterFuse Technology
A patented delivery system created to solve a specific problem: the ingredients with the most anti-wrinkle potential are often the ones least able to get past the skin surface. It amplifies the delivery of intact macromolecules, including injectable-grade hyaluronic acid and peptides, so they arrive where they can do cosmetic work. It is the platform shared across the whole InterFuse range.
Injectable-Grade Hyaluronic Acid
The large-molecule hyaluronic acid category associated with injectable use, formulated here for topical application. Delivered by InterFuse Technology, it targets the appearance of deep expression lines and wrinkles rather than surface dehydration. This is the ingredient that gives the product its no-needle positioning.
Four Additional Hyaluronic Acids
Hyaluronic acid is not one material. Four further molecular weights are included so moisture is bound at different levels of the formula and the skin surface, which is what produces a plump, cushioned look rather than a flat film.
Peptides
Short chains of amino acids that help expression lines appear smoother upon application, giving the product its immediate cosmetic effect. Over time they support the look of firmer, more resilient skin in the areas most affected by repeated movement.
Collagen Complex (Amino Acids, Peptides and Vitamin C)
A supportive complex combining amino acids, peptides and Vitamin C. It is included to support the appearance of firmness and resilience in zones that crease constantly, and the Vitamin C component adds antioxidant character to the formula.
Paraben free, fragrance free, dye free, gluten free, cruelty free and formulated without phthalates. Cosmetic claims only. This product is not intended to diagnose, treat, cure or prevent any disease.
How to Use InterFuse Intensive Treatment LINES in a skinbetter Regimen
InterFuse Intensive Treatment LINES goes on first, before anything else, straight onto clean dry skin. Everything else layers over it, morning and evening.
Step 1: Cleanse (AM and PM)
Step 2: Treat the Lines
Step 3: Seal and Protect
Shopping by concern? Browse fine lines and wrinkles and dehydrated skin, or see everything in the skinbetter science collection.
Explore the InterFuse® Range
One patented delivery platform, three targeted formats, plus the products people most often pair with them.
See the complete range in the skinbetter science collection.
Lines, Filler or Both? Let Us Help You Plan.
A SkinCrew skincare expert can help you decide whether InterFuse Intensive Treatment LINES belongs on its own, alongside InterFuse Treatment Cream FACE & NECK, or as maintenance between in-office appointments. Reach out for a complimentary consultation.
Contact Our Skincare Expertsskinbetter science InterFuse® Intensive Treatment LINES FAQ
What does skinbetter science InterFuse Intensive Treatment LINES do?
InterFuse Intensive Treatment LINES visibly improves deep expression lines and wrinkles without needles. Patented InterFuse Technology carries injectable-grade hyaluronic acid, four additional hyaluronic acids, peptides and a collagen complex into targeted areas. A dermatologist-led trial recorded over 20% improvement in the appearance of fine lines, wrinkles, forehead lines and crow's feet at eight weeks.
How long does skinbetter InterFuse Intensive Treatment LINES take to work?
Peptides help expression lines look smoother immediately on application, but measured change takes longer. In the dermatologist-led clinical trial of 25 patients using it twice daily, improvement was visible in unretouched photography at four weeks and reached over 20% in the appearance of lines, wrinkles and crow's feet by week eight.
Is InterFuse Intensive Treatment LINES a replacement for filler or Botox?
No. InterFuse Intensive Treatment LINES is a cosmetic topical, not an injectable, and it does not replace an in-office treatment. It is chosen by people who prefer to avoid injections altogether and by patients who want a daily topical to use between appointments. Discuss your plan with your treating clinician.
Where exactly should I apply InterFuse Intensive Treatment LINES?
Apply a thin layer only where expression lines form: crow's feet and lines around the eyes, forehead lines, the vertical lines above the upper lip, and smile lines. It goes on first, straight onto clean dry skin, before any cream. Targeted use is why a 15 ml bottle lasts longer than people expect.
What is the difference between InterFuse LINES and InterFuse Treatment Cream FACE & NECK?
LINES is a targeted, intensive treatment for specific expression lines, applied first. InterFuse Treatment Cream FACE & NECK is a peptide-rich cream for the whole face and neck, applied over it. They were studied together: at 12 weeks the pair produced average improvements of 79% in facial skin texture and 50% in lines and wrinkles.
Can I use InterFuse Intensive Treatment LINES with a retinoid?
Yes, and many people do. Apply InterFuse Intensive Treatment LINES first to clean, dry skin and let it absorb, then apply AlphaRet Overnight Cream over the face in the evening. LINES contains no retinoid and no acid, so it adds hydration and smoothing rather than extra exfoliation or irritation.
Can I use InterFuse Intensive Treatment LINES while pregnant?
InterFuse Intensive Treatment LINES contains no retinoid and no alpha hydroxy acid, which is why many people consider it during pregnancy. SkinCrew cannot provide medical advice, however. If you are pregnant, lactating or planning to become pregnant, review the full ingredient list with your physician before starting any new product.
How much is skinbetter InterFuse Intensive Treatment LINES and what sizes are there?
At SkinCrew, InterFuse Intensive Treatment LINES is $145 for the 15 ml size and $245 for the 30 ml size. A 6 x 5 ml travel pack is also available at $312. Because you apply a thin layer only to targeted lines, the 15 ml bottle is a realistic starting size for most people.
Is InterFuse Intensive Treatment LINES worth it?
It is worth it if deep expression lines are your specific concern and you want a topical with published data behind it. The InterFuse platform was evaluated in the Journal of Cosmetic Dermatology, 2022, alongside InterFuse Treatment Cream FACE & NECK, and first presented at the Maui Dermatology Conference in 2017. Results build with consistent twice-daily use.
Does InterFuse Intensive Treatment LINES work on lip lines and crow's feet?
Yes, those are two of its intended target zones. The official directions name lines around the eyes, the forehead, the upper lip and smile lines. In the dermatologist-led eight-week evaluation, crow's feet were among the attributes that improved by over 20% in appearance with twice-daily application.
Where can I buy authentic skinbetter science InterFuse LINES in the US?
skinbetter science is sold only through Authorized Physician Partners. SkinCrew is a Preferred Authorized skinbetter science US Retailer operating under medical direction and sources every unit directly from the brand, so your InterFuse Intensive Treatment LINES is fresh, authentic and never grey-market. Orders ship fast across the United States.
What should I use with InterFuse Intensive Treatment LINES?
Cleanse with Cleansing Gel, apply InterFuse Intensive Treatment LINES to target areas, then InterFuse Treatment Cream EYE around the eyes and InterFuse Treatment Cream FACE & NECK over the face. Add AlphaRet Overnight Cream at night if tolerated, and finish every morning with sunbetter SHEER SPF 70 Sunscreen Lotion.