Epicutis Hydrobiome Serum

⚡ Limited stock - Order by Monday 1PM EST for next-day shipping
Regular price
$165.00
Sale price
$165.00
Regular price
$165.00

A next generation microbiome balancing serum designed to calm inflammation, strengthen the barrier, and restore resilient skin.

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  • Description

  • Key Benefits

  • How to use

  • Ingredients

Description

Size: 50 mL

Skin Concerns: Redness, inflammation, breakouts, barrier damage, microbiome imbalance, sensitivity

Skin Types: All skin types, including sensitive and acne prone skin

Texture: Lightweight fast absorbing serum

 

BALANCE THE MICROBIOME. CALM INFLAMMATION. RESTORE RESILIENT SKIN.

 

Epicutis Hydrobiome Serum is a next generation microbiome balancing treatment designed to restore skin health by calming inflammation, strengthening the skin barrier, and supporting long term microbiome harmony. This advanced EWG Verified formulation combines clinically proven actives that work synergistically to improve skin resilience while targeting visible redness, irritation, and microbiome related breakouts.


At the core of the formula is TCP, a patented TLR2 modulator developed by Signum Biosciences that helps regulate inflammatory signaling while targeting C. acnes and supporting beneficial skin flora. Paired with TPNa, an advanced water soluble form of Vitamin E, the serum delivers antioxidant protection while reinforcing the skin’s natural barrier against environmental stressors.


Lightweight and fast absorbing, Hydrobiome Serum delivers immediate comfort while supporting healthier, calmer, and visibly more resilient skin over time. Ideal for compromised barriers, reactive skin, post treatment recovery, or anyone seeking balanced, healthy skin function.

Key Benefits

How to use

Ingredients

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Epicutis Hydrobiome Serum: Microbiome-Balancing Treatment to Calm Redness & Breakouts

The Epicutis Hydrobiome Serum is a next-generation, EWG Verified microbiome-balancing treatment that calms inflammation, strengthens the barrier, and supports long-term microbiome harmony. At its core is TCP, a patented TLR2 modulator from Signum Biosciences that helps regulate inflammatory signaling while targeting C. acnes and supporting beneficial skin flora — paired with TPNa, an advanced water-soluble Vitamin E for antioxidant protection. Lightweight and fast-absorbing, it delivers immediate comfort and visibly calmer, more resilient skin.

🛡️ Authorized US Epicutis Retailer Guarantee

As an authorized Epicutis retailer, SkinCrew guarantees every order is genuine, fresh, and protected:

✅ 100% Authentic
Sourced through official Epicutis channels — never expired, diverted, or grey-market.
❄️ Fresh, Potent Actives
Proper handling keeps every active at full clinical strength on arrival.

Why the Epicutis Hydrobiome Serum Stands Out

  • Balances the skin microbiome. Patented TCP helps regulate inflammatory signaling and support beneficial flora.
  • Targets redness and breakouts. Helps calm visible redness, irritation, and microbiome-related breakouts.
  • Antioxidant barrier defense. TPNa, a water-soluble Vitamin E, reinforces the barrier against environmental stress.
HYDROBIOME SERUM VS COMMON ANTI-BLEMISH OPTIONS
Feature Epicutis Hydrobiome Niacinamide Serum Benzoyl Peroxide
ApproachMicrobiome balance + TLR2General soothingHarsh antibacterial
Barrier effectStrengthensMild supportCan dry / irritate
Sensitive-skin safeYes (EWG Verified)UsuallyOften not

The Hydrobiome Serum Active Profile

Balance
Patented TCP
A TLR2 modulator that calms inflammation and targets C. acnes.
Protect
TPNa Vitamin E
Water-soluble antioxidant that reinforces the barrier.
Calm
Reduces Redness
Soothes visible irritation and reactivity.
Clean
EWG Verified
An advanced, clean formulation for sensitive, acne-prone skin.

How to Use the Hydrobiome Serum

A lightweight daily serum for reactive, breakout-prone skin.

Step 1: Cleanse

Step 2: Balance

Step 3: Hydrate

Explore the Epicutis Hydrobiome & Lipid Range

Microbiome balance plus barrier repair.

💬

Battling Redness or Breakouts?

A SkinCrew certified skincare expert can help you choose between the Hydrobiome and Lipid lines for your skin. Reach out for a complimentary consultation.

Contact Our Skincare Experts

Epicutis Hydrobiome Serum FAQ

What does the Epicutis Hydrobiome Serum do?

It is a microbiome-balancing serum that calms inflammation, strengthens the barrier, and targets redness and microbiome-related breakouts using patented TCP and TPNa Vitamin E.

What is TCP?

TCP is a patented TLR2 modulator developed by Signum Biosciences that helps regulate inflammatory signaling, target C. acnes, and support beneficial skin flora.

Is it good for acne-prone skin?

Yes. It is designed for sensitive and acne-prone skin, addressing breakouts through microbiome balance rather than harsh, drying antibacterials.

How do I use it?

Apply to clean skin morning and night. It is lightweight and fast-absorbing, so it layers well under moisturizer and SPF.

Is it EWG Verified?

Yes — it is an EWG Verified formulation, reflecting Epicutis’s clean-ingredient standards.

How is it different from the Lipid Serum?

The Lipid Serum focuses on rebuilding the barrier with lipids and TSC, while the Hydrobiome Serum focuses on microbiome balance and inflammatory signaling — they can be used together.

Can I use it with other actives?

Yes, but introduce actives gradually on reactive skin and apply SPF each morning.

Is it safe during pregnancy?

Its clean, EWG Verified profile is often preferred, but confirm suitability with your healthcare provider during pregnancy or nursing.

Hands-On Note

From the SkinCrew Clinical Desk

Epicutis Hydrobiome Serum is a lightweight, EWG-verified microbiome-balancing serum with TCP (a TLR2 modulator that targets C. acnes) and water-soluble vitamin E that calms inflammation, reinforces the barrier, and supports beneficial skin flora. It suits all skin types, including sensitive and acne-prone skin. Apply to clean skin morning and/or night, before moisturizer.
Best for: All skin types, sensitiveTargets: Hydration, barrier support, soothing
— Reviewed by the SkinCrew Clinical Team, authorized US clinical-skincare specialists.