Epicutis Hydrobiome Serum
- Regular price
- $165.00
- Sale price
- $165.00
- Regular price
- $165.00
A next generation microbiome balancing serum designed to calm inflammation, strengthen the barrier, and restore resilient skin.
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Description
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Key Benefits
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How to use
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Ingredients
Description
Size: 50 mL
Skin Concerns: Redness, inflammation, breakouts, barrier damage, microbiome imbalance, sensitivity
Skin Types: All skin types, including sensitive and acne prone skin
Texture: Lightweight fast absorbing serum
BALANCE THE MICROBIOME. CALM INFLAMMATION. RESTORE RESILIENT SKIN.
Epicutis Hydrobiome Serum is a next generation microbiome balancing treatment designed to restore skin health by calming inflammation, strengthening the skin barrier, and supporting long term microbiome harmony. This advanced EWG Verified formulation combines clinically proven actives that work synergistically to improve skin resilience while targeting visible redness, irritation, and microbiome related breakouts.
At the core of the formula is TCP, a patented TLR2 modulator developed by Signum Biosciences that helps regulate inflammatory signaling while targeting C. acnes and supporting beneficial skin flora. Paired with TPNa, an advanced water soluble form of Vitamin E, the serum delivers antioxidant protection while reinforcing the skin’s natural barrier against environmental stressors.
Lightweight and fast absorbing, Hydrobiome Serum delivers immediate comfort while supporting healthier, calmer, and visibly more resilient skin over time. Ideal for compromised barriers, reactive skin, post treatment recovery, or anyone seeking balanced, healthy skin function.
Key Benefits
How to use
Ingredients
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Epicutis Hydrobiome Serum: Microbiome-Balancing Treatment to Calm Redness & Breakouts
The Epicutis Hydrobiome Serum is a next-generation, EWG Verified microbiome-balancing treatment that calms inflammation, strengthens the barrier, and supports long-term microbiome harmony. At its core is TCP, a patented TLR2 modulator from Signum Biosciences that helps regulate inflammatory signaling while targeting C. acnes and supporting beneficial skin flora — paired with TPNa, an advanced water-soluble Vitamin E for antioxidant protection. Lightweight and fast-absorbing, it delivers immediate comfort and visibly calmer, more resilient skin.
Why the Epicutis Hydrobiome Serum Stands Out
- Balances the skin microbiome. Patented TCP helps regulate inflammatory signaling and support beneficial flora.
- Targets redness and breakouts. Helps calm visible redness, irritation, and microbiome-related breakouts.
- Antioxidant barrier defense. TPNa, a water-soluble Vitamin E, reinforces the barrier against environmental stress.
The Hydrobiome Serum Active Profile
How to Use the Hydrobiome Serum
A lightweight daily serum for reactive, breakout-prone skin.
Step 1: Cleanse
Step 2: Balance
Step 3: Hydrate
Explore the Epicutis Hydrobiome & Lipid Range
Microbiome balance plus barrier repair.
Battling Redness or Breakouts?
A SkinCrew certified skincare expert can help you choose between the Hydrobiome and Lipid lines for your skin. Reach out for a complimentary consultation.
Contact Our Skincare ExpertsEpicutis Hydrobiome Serum FAQ
What does the Epicutis Hydrobiome Serum do?
It is a microbiome-balancing serum that calms inflammation, strengthens the barrier, and targets redness and microbiome-related breakouts using patented TCP and TPNa Vitamin E.
What is TCP?
TCP is a patented TLR2 modulator developed by Signum Biosciences that helps regulate inflammatory signaling, target C. acnes, and support beneficial skin flora.
Is it good for acne-prone skin?
Yes. It is designed for sensitive and acne-prone skin, addressing breakouts through microbiome balance rather than harsh, drying antibacterials.
How do I use it?
Apply to clean skin morning and night. It is lightweight and fast-absorbing, so it layers well under moisturizer and SPF.
Is it EWG Verified?
Yes — it is an EWG Verified formulation, reflecting Epicutis’s clean-ingredient standards.
How is it different from the Lipid Serum?
The Lipid Serum focuses on rebuilding the barrier with lipids and TSC, while the Hydrobiome Serum focuses on microbiome balance and inflammatory signaling — they can be used together.
Can I use it with other actives?
Yes, but introduce actives gradually on reactive skin and apply SPF each morning.
Is it safe during pregnancy?
Its clean, EWG Verified profile is often preferred, but confirm suitability with your healthcare provider during pregnancy or nursing.

